Paclitaxel pka
WebPaclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. CAS No. 33069-62-4 Selleck's Paclitaxel (NSC 125973) has been cited by 372 publications Cancer Cell,202440 (10):1207-1222.e10 Cell Res,202410.1038/s41422-022-00651-9 Cell,2024184 (25):6119-6137.e26 WebPaclitaxel: The risk or severity of adverse effects can be increased when Amiloride is combined with Paclitaxel. ... pKa: 8.7: Not Available: Predicted Properties. Property Value Source; Water Solubility: 0.616 mg/mL: ALOGPS: logP-0.48: ALOGPS: logP-0.5: Chemaxon: logS-2.6: ALOGPS: pKa (Strongest Acidic)
Paclitaxel pka
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WebPaclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. WebPaclitaxel European Pharmacopoeia (EP) Reference Standard Empirical Formula (Hill Notation): C47H51NO14 CAS Number: 33069-62-4 Molecular Weight: 853.91 Beilstein: 1420457 MDL number: MFCD00869953 PubChem Substance ID: 329831102 NACRES: NA.24 Pricing and availability is not currently available. Properties grade pharmaceutical …
WebIn the present study, we have synthesized poly (styrene- co -maleic anhydride), a biocompatible copolymer that was further conjugated with paclitaxel (PTX) via ester linkage and self-assembled to form poly (styrene- co -maleic acid)-paclitaxel (PSMAC–PTX) nanoparticles (NPs). WebPaclitaxel (semisynthetic from Taxus sp.,≥97%); Paclitaxel has been used to study its effects on tumor regression in mouse models of pancreatic ductal adenocarcinoma ; Chemical structure: taxoide; Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-te USEN ApplicationsProductsServicesSupport T7191 All …
WebPaclitaxel (PAC, peak 1); 10-deacetylpaclitaxel (peak 2); 7-epipaclitaxel (peak 3); baccatin III (peak 4); cephalomannine (PAC-related compound A, peak 5); 10-deacetyl-7-epipaclitaxel (PAC-related compound B, peak 6). SHDN SHDN SHDN SHDN SHDN SHDN P$8 PLQ WebPaclitaxel is a diterpene alkaloid originally isolated from the bark of the Pacific Yew tree (Taxus brevifolia). It binds to and stabilizes microtubules, preventing their reorganization during cell division, which leads to cell cycle arrest. ... B-cell CLL/lymphoma 2 (BCL-2) family members, cyclin-dependent kinases, p38 MAPK, PKA, and JNK/SAPK ...
WebQuestion: Caculate the pH of a 10.00 micro M aqueous solution of Paclitaxel (pKa=10.36) Caculate the pH of a 10.00 micro M aqueous solution of Paclitaxel (pKa=10.36) Expert Answer. Who are the experts? Experts are tested by Chegg as specialists in their subject area. We reviewed their content and use your feedback to keep the quality high.
WebAug 31, 2024 · FBXW2 overexpression abrogates the effects of p65 on paclitaxel resistance in vitro and in vivo. ... (PKA) by knockdown or with a PKA inhibitor (H-89). Indeed, PKA … rite aid east ave chicoWebThe microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) … smite official promotional pageWebPaclitaxel is one of the most widely used chemotherapeutic agents thanks to its effectiveness and broad spectrum of antitumor activity. However, it has a very poor aqueous solubility and a limited specificity. To solve these handicaps, a novel paclitaxel-trastuzumab targeted transport nanosystem has been developed and characterized in this work to … smite official the destroyerWebApr 1, 2007 · Meanwhile, Paclitaxel stimulation weakened PKA activity and reduced phosphorylation of VASP analyzed by western blot. However, the inhibiting effect of Paclitaxel on ECV304 cell migration was attenuated by PKA activator Forskolin. Increased PKA activity and phosphorylation expression of VASP were also detected by adding … smite offlineWebPaclitaxel C47H51NO14 CID 36314 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. National Institutes of Health. National Library of … rite aid east 3rd street williamsport parite aid east greenbushWebFeb 18, 2012 · The drug exhibited a pKa value of 10.9, log P value of 2.3, pH dependent solubility, and low artificial membrane permeability. Stability of the drug substance in the in vitro screening media... rite aid eastern ave schenectady ny