Tfrc-121
Web19 May 2024 · MYCN is a regulator of GPX4-dependent ferroptosis. To study MYCN-dependent cellular processes in NB, we examined a collection of 147 genes essential for the survival of MYCN-amplified NB cells 17 ... WebTransferrin receptor 1 (TfR1), encoded by the TFRC gene, is the gatekeeper of cellular iron uptake for cells. A variety of molecular mechanisms are at work to tightly regulate TfR1 …
Tfrc-121
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WebTransferrin receptor (TfR) expression is regulated by the iron regulatory protein system.94,99 Iron accumulation has been associated with cell damage, so the TfR … Web13 May 2024 · TFRC-mediated iron import is at the center of this novel feed-forward loop to facilitate colonic epithelial cell survival. Mechanistically, disruption of TFRC led to a …
WebTFRC is a Diagnostic and Prognostic Indicator. Firstly, we use TCGA and GEO database to build ROC curve, and found the AUC = 0.856 (GSE16515) and 0.742 (TCGA and GTEx), … Web6 Sep 2024 · The TFRC gene encodes the transferrin receptor, which is important for cellular iron uptake. Circulating apotransferrin (TF; 190000) binds 2 Fe (3+) ions to form holotransferrin, which binds to TFRC. The TFRC-holotransferrin complex is internalized by receptor-mediated endocytosis (summary by Jabara et al., 2016 ).
Web9 Aug 2024 · The transferrin receptor (TfR, TfR1, CD71), encoded by the TFRC gene in humans, is an integral component of iron metabolism and erythrocyte production. 1 The highest expression of TfR is seen in the bone marrow on developing erythroblasts, which require intake of circulating iron for hemoglobin synthesis. 2,3 The 2 key ligands of TfR … WebTFRC INFORMATION. Proteini. Full gene name according to HGNC. Transferrin receptor. Gene namei. Official gene symbol, which is typically a short form of the gene name, …
Web16 Apr 2024 · Then, a TFRC promoter reporter vector with precise deletion of PBS (Del-YAP) was constructed, and it was found that transfection of the Del-YAP plasmid led to total loss of TFRC promoter activity ...
WebUpon stimulation, positively regulates T and B cell proliferation through iron uptake ( PubMed: 26642240 ). Acts as a lipid sensor that regulates mitochondrial fusion by … starting a rhododendron from a cuttingWeb16 Mar 2024 · The bioinformatics analysis showed that TFRC plays a role in the occurrence and development of pancreatic cancer mainly through signaling pathways (including cell adhesion molecule binding, condensed chromosomes, chromosome segregation, and cell cycle checkpoints). pete\u0027s barber shop tiverton ri four squaresWebThe Freedoms & Rights Coalition. 45,649 likes · 414 talking about this. "We may separately have very different frustrations, but we collectively stand together as we all ag pete\u0027s beachWebFig. 1. The central biochemical event of ferroptotic cancer cell death. The central biochemical event of ferroptosis is involved in iron accumulation and lipid peroxidation, which leads to oxidative injury and cell death. ROS, reactive oxygen species. Iron is an important trace element in many species. pete\u0027s barber shop shelby townshipWeb21 Mar 2024 · TFRC (Transferrin Receptor) is a Protein Coding gene. Diseases associated with TFRC include Immunodeficiency 46 and Combined Immunodeficiency.Among its … starting a riding lawn mowerWeb23 Jan 2024 · Background Transferrin receptor 1 (TfR1), encoded by TFRC, is a key regulator of iron homeostasis and plays important roles in many diseases, including cancers. Objective To decipher the underlying molecular functions of TfR1 based on its influence on transcriptome profile in cancer cells. Methods In this study, we first identified the … starting armor dai frostyWebTwin Falls Reformed Church, Twin Falls, Idaho. 1,901 likes · 77 talking about this · 2,492 were here. The Gospel Is Real • The Gospel Changes Everything pete\u0027s beer distributor hours